The purpose of this research study is to identify genes that are involved in the development of Inflammatory Bowel Disease (IBD) at a young age (less than 8 years of age). This is a case-control study of IBD patients which compares children with symptoms and/or diagnosis of IBD.

The purpose of this research study is to collect different types of samples (such as stool, swabs, urine) to form a biorepository. This repository will provide valuable samples from people with and without IBD so that investigators can learn more about the cause of IBD, and different therapies that could be used to treat it. These samples will be used for future gastrointestinal research. Because technology and scientific understanding may advance quickly, it is not yet known what specific studies the samples may be used for. 

The purpose of this study is to compare the genes of African American children and adults who have inflammatory bowel disease (IBD) with the genes of those who do not have IBD. Genes are pieces of hereditary material found in human cells. How an individual's genes cause intestinal inflammation in IBD is still being tested and not much is known about the association between genes and IBD in individuals with African ancestry. We hope to understand which genes cause IBD and if certain genes can help doctors personalize treatment for patients with IBD. For more information please contact IBDResearch@email.chop.edu. 

The Harmony Valve study is for patients in need of pulmonary valve replacement. The HarmonyTM Valve is a transcatheter pulmonary valve specifically designed for patients in need of a pulmonary valve replacement who do not want to have to undergo surgery. Surgical placement of a new valve is the most common treatment for a nonworking pulmonary valve, however, there are many risks associated with open heart surgery and it is followed by months of recovery. A less invasive approach for treatment is now available by placement of a pulmonary valve by a transcatheter procedure. The HarmonyTM Valve has not been approved by the FDA yet for commercial use and is only available by participating in the study., Please contact Dr. Matthew Gillespie (gillespie@email.chop.edu) if you or your patient may be interested in participating in the trial of this device., 

The purpose of this research study is to test a new method of cell processing for stem cell transplants with an unrelated donor or partially matched related donor for patients with BMF who do not have a well matched related donor. The new method is called alpha/beta T cell and B cell depletion using a device called CliniMACs.  We want to see if this method can reduce some of the complications of the transplant and decrease the time it takes for the new stem cells to establish a new immune system.

The purpose of this research study is to evaluate the side effects of using proton radiation therapy for kidney tumors.  Proton radiation can limit the radiation exposure of normal tissues and decrease the side effects from radiation compared to the current standard methods of treating kidney tumors with x-ray radiation. Proton radiation has proven to be as effective at treating tumors as current standard radiation methods in other disease sites, but it has not been used for treatment of kidney tumors in children.

The purpose of this research study is to find out if stem cells from umbilical cord blood (collected at birth) can strengthen the muscle of the right side of the heart for patients diagnosed with Hypolplastic Left Heart Syndrome who are scheduled to undergo the Stage II Glenn surgical procedure.

The goals of this research study are to learn more about acute recurrent and chronic pancreatitis in order to better understand the disease in the hopes of enhancing future treatment options. If you and your child agree to participate you will each be asked to: meet with the study team at your annual check-up, complete questionnaires about medical history, family history, and quality of life, agree to a one-time blood or saliva sample collection. All participants will be compensated for their time and effort. If you would be interested in participating, please contact study coordinator Lucia Sanchez by phone at 267-426-8411, or email at sanchezlc@email.chop.edu. 

We know very little about how the bladder to brain connections work in children.  The most common thing we hear from children who are having urinary leakage is "I was not aware my bladder was full."  Is this full bladder message getting lost?  In this study we will measure brain wave activity non invasively after you have drank some Gatorade to get a full bladder and after you have voided.  The total time needed for this study will be about 3 to 4 hours.

This is a clinical trial to study the use of Tadekinig alfa or placebo (medication) in the treatment of NLRC4 MAS mutation or XIAP deficiency. This study involves taking the medication every 48 hours for up to 26 weeks. Participants will also be required to attend up to 14 in-person study visits to review their disease state while they are taking the medication. Compensation for time and travel related to study visits may be provided to qualified participants.